List of variables being considered

Variables by Category

Demographics/Baseline

Is the patient currently pregnant or was pregnant in the last 6 weeks?

Vitals

Capillary refill ≥ 3 sec

Temperature

Shock

  • defined by:
    • Blood pressure
    • Capillary refill
    • Cold peripheries
  • All listed vital signs were considered important for assessing shock, and a separate shock item was added.
  • A clear and consistent definition will need to be included

Level of consciousness

  • Level of consciousness: Discussion is needed on whether AVPU or GCS should be retained as the preferred assessment tool.

Symptoms

Signs of ascites and pleural effusion

Bleeding

❓ WHO Warning Signs

  • Abdominal pain or tenderness
  • Persistent vomiting
  • Clinical fluid accumulation
  • Mucosal bleed
  • Lethargy, restlessness
  • Liver enlargement >2 cm
  • Laboratory: increase in HCT concurrent with rapid decrease in platelet count

Comorbidities

Diabetes (type 1 or type 2)

Obesity

Hypertension

❓ Chronic kidney disease

❓ Chronic heart disease (e.g., heart failure, coronary artery disease)

❓ Chronic liver disease

❓ Immunosuppressive condition or Immunosuppressive medication

Laboratory and Imagery

Creatinine

Hematocrit

❓ DENV serotype

Complications

Severe Organ Impairment

  • Respiratory Complications. Including but not limited to:
    • Acute Respiratory Distress Syndrome (ARDS)
  • Cardiac Complications. Including but not limited to:
    • Cardiac arrest/ Cardiac arrhythmia / Shock
    • Myocarditis / Pericarditis
  • Liver Complications. Including but not limited to:
    • Acute hepatitis
    • Hepatic encephalopathy (any grade) / Severe liver disease (new onset)
  • Renal Complications. Including but not limited to:
    • Acute renal injury / Acute renal failure
    • Urine flow rate
  • Neurological Complications. Including but not limited to:
    • Encephalitis / Meningitis
    • Focal neurological signs

Fluid Overload

  • Pleural effusion / Ascites

❓ Severe bleeding

Diagnosis

Dengue Diagnosis

Vaccinations

Vaccinated for dengue

Treatments

Blood transfusion

Platelets

❓ Diuretics

❓ Highest level of care

❓ Renal replacement therapy (e.g., dialysis)

❓ Vasopressive Support

❓ Respiratory Support

❓ NSAIDs

Outcomes

Outcome at discharge

Date of discharge/transfer

Thank you